Activity Number
76
Editable
Overview and Learning Objectives
Assessment
Central Concepts
Textbook References
Activity Credits
Requirements

How a Protein Gets Its Shape: The Role of Charge

Interactive, scaffolded model

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This Activity Requires:

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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Overview and Learning Objectives

Students will be able to:

  • Discuss the role of charged areas of molecules in folding polymer chains into specific shapes.
  • Reason about the forces that bring polymers together into complex cellular structures.
  • Give several examples of cellular machinery and compare them to macroscopic tools and machines.

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Assessment

See question 1 from the following pre/post- test:

http://www.concord.org/~barbara/workbench_web/unitV/prepost_test.html

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Central Concepts

Key Concept:

Monomers with different charges attract each other; those with identical charges repel each other. The interactions among charged monomers within the polymer help determine the polymer shape.

Additional Related Concepts

Biology

  • Sickle Cell Anemia

Molecular Biology

  • Amino acid
  • Protein
  • Protein Folding
  • Self-assembly

Physics/Chemistry

  • Charge

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Textbook References

  • Biology (Miller and Levine) Prentice Hall 5th Edition - Unit 2: Chapter 7 - Nucleic Acids and Protein Synthesis
  • Biology: Exploring Life - Chapter 5: The Molecules of Life
  • BSCS Blue (8th Edition) - Chapter 9: Expressing Genetic Information
  • Web of Life - Chapter 8: Protein Synthesis

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Activity Credits

Created by CC Project: Molecular Workbench using Molecular Workbench

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Requirements

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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NSF Logo
These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701, EIA-0219345, DUE-0402553, and 0628181.

Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect
the views of the National Science Foundation.