Activity Number
300
Editable
Overview and Learning Objectives
Central Concepts
Textbook References
Activity Credits
Requirements

Protein Conservation: A View into Proteomics (a 6-page activity)

Interactive, scaffolded model

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  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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Overview and Learning Objectives

Students review aspects of protein structure and folding and then move to 3D molecules, evaluating the consequences of both conservative and non-conservative substitutions in protein sequences. The activity culminates in a comparison of human, rat and bacterial enzymes; students discuss why it is be important for some regions to be conserved.

Students will be able to:

• explain the basic forces at work in protein folding

• differentiate conservative and non-conservative substitutions in mutations.

• compare human, rat and bacterial enzymes and discuss why it is be important for some to be conserved.

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Central Concepts

Key Concept:

Finding similarities in sequences is greatly aided by computers.

Additional Related Concepts

Molecular Biology

  • Protein Folding
  • Protein structure

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Textbook References

  • Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 13: How Populations Evolve
  • Biology: Concepts and Connections (Pearson) 5th Edition - Chapter 15: Tracing Evolutionary History
  • Biology: The Dynamics of Life - Chapter 13: Genetic Technology
  • Cell Biology (Pollard and Earnshaw) Saunders 2002 - Chapter 18: Protein Synthesis and Folding in the Cytoplasm
  • Web of Life - Chapter 8: Protein Synthesis

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Activity Credits

Created by CC: Molecular Literacy using Molecular Workbench

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Requirements

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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NSF Logo
These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701, EIA-0219345, DUE-0402553, and 0628181.

Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect
the views of the National Science Foundation.