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Students review aspects of protein structure and folding and then move to 3D molecules, evaluating the consequences of both conservative and non-conservative substitutions in protein sequences. The activity culminates in a comparison of human, rat and bacterial enzymes; students discuss why it is be important for some regions to be conserved.
Students will be able to:
• explain the basic forces at work in protein folding
• differentiate conservative and non-conservative substitutions in mutations.
• compare human, rat and bacterial enzymes and discuss why it is be important for some to be conserved.
Finding similarities in sequences is greatly aided by computers.
Additional Related Concepts