Activity Number
21
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Central Concepts
Textbook References
Extensions and Connections
Activity Credits
Requirements

Experiment on an All-Hydrophilic Polypeptide (an interrelated set of 4 models)

Interactive model, with minimal support

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Central Concepts

Key Concept:

Folding and unfolding of a polypeptide with 20 glutamic acids.

Additional Related Concepts

Concept Map Available

Molecular Biology

  • Amino acid
  • Polymer
  • Primary structure
  • Protein
  • Protein Folding
  • Protein structure

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Textbook References

  • Biology (Miller and Levine) Prentice Hall 5th Edition - Unit 2: Chapter 7 - Nucleic Acids and Protein Synthesis
  • Biology: Concepts and Connections (Pearson) 5th Ed. - Chapter 3: The Molecules of Cells
  • Biology: Exploring Life - Chapter 5: The Molecules of Life
  • BSCS Blue (8th Edition) - Chapter 23 - Immune System
  • Cell Biology (Pollard and Earnshaw) Saunders 2002 - Chapter 18: Protein Synthesis and Folding in the Cytoplasm
  • Web of Life - Chapter 8: Protein Synthesis

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Extensions and Connections

Additional Protein Activities of Interest in the Database

The Structure of Proteins: Insulin (for high school)(#236)

The Structure of Proteins: Insulin (for college)(#228)

Forces for Folding: Charge

Effect of Charges on Folding: A Strongly Polar Conformation (#213) Effect of Charges on Folding: An Alternately-Charged Conformation (#209) Electrostatic Self-Assembly (#157) How a Protein Gets Its Shape: The Role of Charge (#76) Intermolecular interactions of proteins in water (#211)

Coding for Folds

How a Protein Gets Its Shape: The Role of DNA as Code (#161) Protein Shaping: (Module 4-5 days) From DNA to Proteins (#159)

Particular Proteins

Melittin Protein (#87) Sickle Cell Anemia Fragment (#162)

General teaching proteins

Protein folding starting from a random coil: a long polypeptide (#207) Amino Acids and Water: 20 Alanine Model (#160) Protein Polymer with 20 Glutamic Acids (#21) Protein Polymer with 48 Amino Acids (#22)

The Effect of Structures and Subforces on Protein (#132)

Functions

Docking: Binding of Complementary Surfaces (#154) Recognition and Self-Assembly

Tool to see a set of proteins: Molecular Viewer (#185)

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Activity Credits

Created by CC Project: Molecular Workbench using Molecular Workbench

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Requirements

  • Java 1.5+ - Java 1.5+ is available for Windows, Linux, and Mac OS X 10.4 and greater. If you are using Mac OS X 10.3, you can download MW Version 1.3 and explore within it instead.

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NSF Logo
These materials are based upon work supported
by the National Science Foundation under grant numbers
9980620, ESI-0242701, EIA-0219345, DUE-0402553, and 0628181.

Any opinions, findings, and conclusions or recommendations expressed in this
material are those of the author(s) and do not necessarily reflect
the views of the National Science Foundation.